Enzyme Discovery with ActSeek
ActSeek is the active-site search engine behind ActSeekN. It supports enzyme discovery by matching structural patterns of catalytic and binding residues.
ActSeek is described in Castillo S, Ollila S, ActSeek: Fast and accurate search algorithm of active sites in Alphafold database, Bioinformatics, 2025; btaf424 — https://doi.org/10.1093/bioinformatics/btaf424 .
Code and Documentation
The ActSeek source code and usage documentation are available at https://github.com/vttresearch/ActSeek .
ActSeek Workflow
The schematic below summarizes how ActSeek performs active-site based discovery.
